Mechanistic Modeling Approach to Prediction & Analysis of Clinical Trial Results in Neurodegeneration

Time: 10:35 am
day: Day One


  • Quantitative system pharmacology (QSP) modeling of clinical trials facilitates interpretation of information provided by biomarkers.
  • QSP methods allows for investigation of interaction between pathological mechanisms, biomarkers and treatment: example for aducanumab clinical trial.
  • Combinatorial therapy efficacy on endpoints, intrinsic mechanisms and
    biomarkers can be potentially predicted by QSP